Genetic and molecular aspects of sport performance

Summary In summary, the full range of genetic variation responsible for human variability in athletic per-formance is likely to include both rare and com-mon polymorphisms. The recent history of genetic research into the causes of complex human diseases provides reason for both caution and optimism that many such variants can and will be found—provided that we remain aware of the challenges and use methods capable of sampling all of the genetic information available from human populations. Acknowledgments Development of the statistical methods described in this report was supported in part by U.S. National Institute of Mental Health grant MH59490 and carried out in computing facilities funded in part by the AT&T Foundation. Acquisition of lymphocyte expression phenotypes was made possible by the generous support of the Azar/Shepperd Family Foundation of San Antonio, Texas. The authors declare no competing interests. Minor allele frequency(a)Relative frequency0.00.0 0.1 0.2 0.3 0.4 0.50.10.20.30.40.50.60.767.8% < 0.0575.8% < 0.10Total number of variants = 599 in 47 genes