Gene-Environment Interactions and Obesity

Abstract This chapter discusses several aspects of gene-environment interactions, beginning with conceptual and statistical models, followed by various study designs for identifying gene-environment interactions. It summarizes results from both intervention and observational studies of gene-environment interactions on obesity and weight change. Finally, it discusses methodological issues in the study of gene-environment interactions, including sample size requirements, the problem of multiple comparisons, lack of replication, and study designs.