Gender and Age Normalization and Ventilation Efficiency During Exercise in Heart Failure with Reduced Ejection Fraction

The percentage of predicted VE/VCO₂ slope value strengthens the prognostic power of VE/VCO₂ in severe HF patients, and it should be preferred over the absolute value for HF prognostication. Furthermore, the widespread use of VE/VCO₂ slope expressed as percentage of predicted value can improve our ability to identify HF patients at high risk, which is a goal of utmost clinical relevance.