Functions of Paracrine PDGF Signaling in the Proangiogenic Tumor Stroma Revealed by Pharmacological Targeting

Kristian Pietras; Jessica Pahler; Gabriele Bergers; Douglas Hanahan

doi:10.1371/journal.pmed.0050019

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Functions of Paracrine PDGF Signaling in the Proangiogenic Tumor Stroma Revealed by Pharmacological Targeting

Article 2008 en

Abstract

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This study illustrates the therapeutic benefits in a mouse model of human cervical cancer of mechanism-based targeting of the stroma, in particular cancer-associated fibroblasts. Drugs aimed at stromal fibroblast signals and effector functions may prove complementary to conventional treatments targeting the overt cancer cells for a range of solid tumors, possibly including cervical carcinoma, the second most common lethal malignancy in women worldwide, for which management remains poor.

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Functions of Paracrine PDGF Signaling in the Proangiogenic Tumor Stroma Revealed by Pharmacological Targeting

Abstract

Discussion(0)

Related publications

Abstract A32: Colorectal cancer stroma: Tumor cells in disguise

Epigenetic <i>SMAD3</i> Repression in Tumor-Associated Fibroblasts Impairs Fibrosis and Response to the Antifibrotic Drug Nintedanib in Lung Squamous Cell Carcinoma

Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function.

mPGES-1-expressing bone marrow-derived cells enhance tumor growth and angiogenesis in mice

Data from Epigenetic &lt;i&gt;SMAD3&lt;/i&gt; Repression in Tumor-Associated Fibroblasts Impairs Fibrosis and Response to the Antifibrotic Drug Nintedanib in Lung Squamous Cell Carcinoma

Data from Epigenetic <i>SMAD3</i> Repression in Tumor-Associated Fibroblasts Impairs Fibrosis and Response to the Antifibrotic Drug Nintedanib in Lung Squamous Cell Carcinoma