Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors

Bram Herpers; Berina Eppink; Mark I. James; Carme Cortina; Adrià Cañellas‐Socias; Sylvia F. Boj; Xavier Hernando‐Momblona; Dominik Głodzik; Rob C. Roovers; Marc van de Wetering; Carina Bartelink-Clements; Vanessa Zondag-van der Zande; Jara García Mateos; Kuan Yan; Lucia Salinaro; Abdul Basmeleh; Szabolcs Fátrai; David Maussang; Jeroen J. Lammerts van Bueren; Irene Chicote; Garazi Serna; Laia Cabellos; Lorena Ramírez; Paolo Nucíforo; Ramón Salazar; Cristina Santos; Alberto Villanueva; Camille Stephan‐Otto Attolini; Elena Sancho; Héctor G. Pálmer; Josep Tabernero; Michael R. Stratton; John de Kruif; Ton Logtenberg; Hans Clevers; Leo Price; Robert G.J. Vries; Eduard Batlle; Mark Throsby

doi:10.1038/s43018-022-00359-0

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