Functional Connectivity From Disease Epicenters in Frontotemporal Dementia

Federica Agosta; Edoardo Gioele Spinelli; Silvia Basaia; Camilla Cividini; Francesco Falbo; Costanza Pavone; Nilo Riva; Elisa Canu; Veronica Castelnovo; Giuseppe Magnani; Francesca Caso; Paola Caroppo; Sara Prioni; Cristina Villa; Lucio Tremolizzo; Ildebrando Appollonio; Vincenzo Silani; Keith A. Josephs; Jennifer Whitwell; Massimo Filippi

doi:10.1212/wnl.0000000000207277

Abstract

1 min read

Our findings demonstrate that each FTD syndrome is associated with a characteristic interplay of decreased and increased functional connectivity with the disease epicenter, affecting both direct and indirect connections. SFC revealed novel insights regarding the topology of functional disconnection across FTD syndromes, holding the promise to be used to model disease progression in future longitudinal studies.

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