Fruit and Vegetable Intake and Coronary Heart Disease

Letters16 July 2002Fruit and Vegetable Intake and Coronary Heart DiseaseKaumudi J. Joshipura, ScD, Frank B. Hu, MD, and Walter C. Willett, MDKaumudi J. Joshipura, ScDHarvard School of Public Health Boston, MA 02115 (Joshipura, Hu, Willett)Search for more papers by this author, Frank B. Hu, MDHarvard School of Public Health Boston, MA 02115 (Joshipura, Hu, Willett)Search for more papers by this author, and Walter C. Willett, MDHarvard School of Public Health Boston, MA 02115 (Joshipura, Hu, Willett)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-2-200207160-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:The suggestion by Drs. Alves-Rodrigues and Thomas that the cardioprotective effect of green leafy vegetables may be related to high lutein levels is based on an animal study of lutein and arteriosclerosis (1) and a study among humans examining the relation between lutein and other antioxidants and coronary disease (2). In our study, we mentioned that antioxidant vitamins, folate, fiber, and such minerals as potassium may contribute to the apparent beneficial effects of fruits and vegetables, and we agree that lutein may also partly explain this benefit.Dr. Lindenauer and colleagues propose a new term, NNEB, as a ...References1. Dwyer JH, Navab M, Dwyer KM, Hassan K, Sun P, Shircore A, et al . Oxygenated carotenoid lutein and progression of early atherosclerosis: the Los Angeles atherosclerosis study. Circulation. 2001;103:2922-7. [PMID: 11413081] CrossrefMedlineGoogle Scholar2. Howard AN, Williams NR, Palmer CR, Cambou JP, Evans AE, Foote JW, et al . Do hydroxy-carotenoids prevent coronary heart disease? A comparison between Belfast and Toulouse. Int J Vitam Nutr Res. 1996;66:113-8. [PMID: 8843985] MedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Harvard School of Public Health Boston, MA 02115 (Joshipura, Hu, Willett) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Effect of Fruit and Vegetable Intake on Risk for Coronary Heart Disease Kaumudi J. Joshipura , Frank B. Hu , JoAnn E. Manson , Meir J. Stampfer , Eric B. Rimm , Frank E. Speizer , Graham Colditz , Alberto Ascherio , Bernard Rosner , Donna Spiegelman , and Walter C. Willett Fruit and Vegetable Intake and Coronary Heart Disease Alexandra Alves-Rodrigues and Boban Thomas Fruit and Vegetable Intake and Coronary Heart Disease Peter Lindenauer , Darius A. Rastegar , and Dorothea von Goeler Metrics 16 July 2002Volume 137, Issue 2Page: 144KeywordsAdverse reactionsAge distributionAntioxidantsCoronary heart diseaseFolic acidPotassiumRelative riskStable coronary artery diseaseVitamins ePublished: 16 July 2002 Issue Published: 16 July 2002 CopyrightCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...