Fluorescence Imaging: Lipid‐PEG‐Folate Encapsulated Nanoparticles with Aggregation Induced Emission Characteristics: Cellular Uptake Mechanism and Two‐Photon Fluorescence Imaging (Small 23/2012)

On page 3655, B. Liu and co-workers develop a one-step procedure to produce twophoton absorption nanoprobes with bright red/near-infrared fluorescence. The nanoprobes are created by encapsulating luminogens with aggregation-induced emission characteristics into a folate-functionalized lipid–PEG polymer matrix. The nanoprobes, which show good biocompatibility, are internalised into cancer cells and easily detected at a depth of 400 μm, a promising result for in vitro and in vivo imaging and diagnosis.