First Example of a 4-Amino-1,2,4,6-thiatriazine 1,1-Dioxide Derivative

For the first time, an N4-amino derivative of 1,2,4,6-thiahiazine 1.1dioxide (5) was prepared by cyclocondensation reaction of the appropriate sulfamoylcarbamate (3) with hydrazine.Reaction of 3 with ammonia yielded the cyclic 4H-derivative (4j.Nucleophilic substitution reactions of 4 and 5 with hydrazine, as well as condensation of 5 with ethyl orthoformate were achieved.The antiprotozoal and anti-HIV properties of the new compounds were evaluated, but none of them showed significant biological activities.