Figure S6 from ERBB4-Mediated Signaling Is a Mediator of Resistance to PI3K and BTK Inhibitors in B-cell Lymphoid Neoplasms

<p>Expression levels of surface ERBB4 and pERBB4 was measured by FACS (A) and immunoblotting (B) in Karpas1718 parental and resistant. (A) Two independent experiments were performed: exp1 (left panel) and exp2 (right panel). Density plots show the median MFI values of two replicates from each experiment: negative control (dotted black), parental (grey), resistant (red). Results are presented from Welch Two Sample test performed on MFI values of the two experiments. (B) Immunobloting for total (grey) and phospho (red) ERBB4 in parental (left) and resistant (right) Karpas1718 cells. Representative image of two independent experiments. Data on the barplot represents the mean of two experiments, errors bars represent standard deviation of the mean. * for p<0.05 from a t-test.</p>