Figure S3 from ERBB4-Mediated Signaling Is a Mediator of Resistance to PI3K and BTK Inhibitors in B-cell Lymphoid Neoplasms

<p>(A) Multidimensional scaling plot showing a 2-dimensional projection of distances across parental and resistant clones for RNA (GEP, top left), methylation (top right) and miRNA (bottom left) profiles. Magenta dots for resistant and pink for parental. (B) Vulcano plots on methylation (top left), gene expression (RNA-seq, top right) and microRNA (RNA-seq, bottom left) profiles of Karpas1718 resistant compared to parental. GEP-miRNA profiles integration. Moderated t-test (limma R Package) was performed comparing resistant to parental: delta Beta-value (methylation), fold change (RNA-seq), adj.P-value for Bonferroni correction of the nominal p-value. Dots represents genes and triangles represent miRNAs. Red corresponds to higher values in resistant, and blue higher values in parental. The genes or miRNAs inversely correlated with methylation are highlighted in darker color: hypomethylated and overexpressed in dark red (neg-corr UP) and hypermethylated and repressed in dark blue (neg-corr DN).</p>