Figure 1 from Discovery and Evaluation of Biomarkers for Triple-Negative Breast Cancer Subtypes Uncovers Patient Stratification and Targeted Therapeutic Strategies

<p>Identification of BaC identity markers expressed in the basal compartment of healthy human breast. <b>A,</b> Schematic representation of a mammary gland duct cross-section, showing BaCs (blue) and LCs cells (red). ERα<sup>pos</sup> and ERα<sup>neg</sup> statuses are indicated by nuclear color. <b>B,</b> Integrated UMAP plot showing epithelial cell clustering from three murine scRNA-seq datasets. Color coding differentiates between BaCs (blue), ERα<sup>pos</sup> LC (red), and ERα<sup>neg</sup> LCs (green). <b>C,</b> UMAP plots showing the signature score of the top 20 DEGs associated with each epithelial compartment. Signature scores are color-coded from low (gray) to high (blue). <b>D,</b> UMAP plots showing expression levels of the top 10 BaC-associated genes across the integrated human dataset. Color gradient indicates expression levels from low (blue) to high (red). <b>E,</b> Representative IHC staining of breast tissue consecutive serial sections showing proteins expression of candidate BaC-associated genes. Scale bar, 50 μm. Arrows in the APOE panel highlight expression restricted to stromal cells. <b>A,</b> Created in BioRender. Rodilla, V. (2026) <a href="https://BioRender.com/qpb7bux" target="_blank">https://BioRender.com/qpb7bux</a>.</p>