Fever in uncomplicated Plasmodium falciparum infection: effects of quinine and paracetamol

The effects of quinine and paracetamol on fever were studied in 21 adult patients with acute uncomplicated falciparum malaria. Quinine alone (n = 7) had no significant effect on fever, whereas paracetamol given 2 h after quinine (n = 7) or 2 h before quinine (n = 7) reduced temperature by a mean of 2·1 °C (standard deviation [sd] 0·95) and 2·1 °C (sd 0·79) respectively. A temperature reduction of 1 °C was associated with a mean decrement of 9·7 beats/min (sd 3·3) in the pulse rate. Quinine does not possess useful antipyretic activity.