FEN1-Generated Oxidized DNA Fragments Escape Mitochondria via mPTP- and VDAC-Dependent Channels to License NLRP3 Inflammasome and STING Activation

Hongxu Xian; Kosuke Watari; Elsa Sánchez‐López; Gerald S. Shadel; Michael Karin

doi:10.2139/ssrn.4022698

Related publications

Article2022

Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

Hongxu Xian, Kosuke Watari, Elsa Sánchez‐López, Joseph Offenberger, Janset Onyuru, Harini Sampath, Wei Ying, Hal M. Hoffman, Gerald S. Shadel, Michael Karin

Article2016

NF-κB restricts NLRP3 inflammasome activation via p62-dependent mitophagy which eliminates mitochondrial signals

Zhenyu Zhong, Atsushi Umemura, Elsa Sánchez‐López, Shuang Liang, Shabnam Shalapour, Jerry Wong, Feng He, Daniela Boassa, Guy Perkins, Syed R. Ali, Matthew G McGeough, Mark H. Ellisman, Ekihiro Seki, Åsa B. Gustafsson, Hal M. Hoffman, María T. Díaz‐Meco, Jorge Moscat, Michael Karin

Article2021

Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation

Hongxu Xian, Yuan Liu, A. Nilsson, Raphaella Gatchalian, Timothy R. Crother, Warren G. Tourtellotte, Yi Zhang, Germán Rodrigo Alemán-Muench, Gavin Lewis, Weixuan Chen, Sarah Kang, Melissa Luevanos, Dorit Trudler, Stuart A. Lipton, Pejman Soroosh, John R. Teijaro, Juan Carlos de la Torre, Moshe Arditi, Michael Karin, Elsa Sánchez‐López

Article2018

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

Zhenyu Zhong, Shuang Liang, Elsa Sánchez‐López, Feng He, Shabnam Shalapour, Xue-Jia Lin, Jerry Wong, Siyuan Ding, Ekihiro Seki, Bernd Schnabl, Andrea L. Hevener, Harry B. Greenberg, Tatiana Kisseleva, Michael Karin

Article2013

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

Takuma Misawa, Michihiro Takahama, Tatsuya Kozaki, Hanna Lee, Jian Zou, Tatsuya Saitoh, Akira Shizuo

Nature Immunology