Favorable Effect of Cotransfection with TGF-β and CTLA4Ig of the Donor Kidney on Allograft Survival

Susanna Tomasoni; Lorena Longaretti; Nadia Azzollini; Elena Gagliardini; Marilena Mister; Thomas Buehler; Giuseppe Remuzzi; Ariela Benigni

doi:10.1159/000077611

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Favorable Effect of Cotransfection with TGF-β and CTLA4Ig of the Donor Kidney on Allograft Survival

Article 2004 en

Abstract

1 min read

Overexpression of AdTGF-beta3 concomitant with the blockade of the CD28/B7 pathway by AdCTLA4Ig induces strong immunosuppression that occasionally allows the acceptance of a fully major histocompatibility complex mismatched renal graft.

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