Driven by the malaria-protective effect of sickle-cell trait, balancing selection results in hemoglobin S equilibrium allele frequencies of between 15% and 20% in areas of high Plasmodium falciparum transmission in sub-Saharan Africa. From this we estimate that the malaria-attributable childhood mortality in the pretreatment era was between 15% and 24%.
Sophie Uyoga, James A Watson, Perpetual Wanjiku, J. C. Rop, Johnstone Makale, AW Macharia, SN Kariuki, GM Nyutu, Shebe Mohammed, Moses Mosobo, Neema Mturi, KA Rockett, CJ Woodrow, Arjen M. Dondorp, Kathryn Maitland, Sir Nicholas White, T Williams
Sophie Uyoga, James A Watson, Perpetual Wanjiku, J. C. Rop, Johnstone Makale, Alexander W. Macharia, Silvia N. Kariuki, Gideon Nyutu, Shebe Mohammed, Moses Mosobo, Neema Mturi, Kirk A. Rockett, Charles J. Woodrow, Arjen M. Dondorp, Kathryn Maitland, Sir Nicholas White, Thomas N. Williams
Walter Taylor, Htee Khu Naw, Kathryn Maitland, Thomas N. Williams, Melissa C. Kapulu, Umberto D’Alessandro, James A. Berkley, Philip Bejon, Joseph Okebe, Jane Achan, Alfred Amambua‐Ngwa, Muna Affara, Davis Nwakanma, Jean‐Pierre Van Geertruyden, Muhindo Mavoko, Pascal Lutumba, Junior Matangila, P Brasseur, Patrice Piola, Rindra Vatosoa Randremanana, Estrella Lasry, Caterina Fanello, ,
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