Immunosurveillance is generally conceived as a mechanism through which the immune system detects and eliminates (pre-)malignant cells, thus reducing the risk of developing cancer. A recent paper by Ovadya et al. demonstrates that knockout of the gene coding for perforin-1 causes accelerated accumulation of senescent cells in multiple mouse organs, thereby speeding up the aging process. These results suggest that immunosurveillance plays a much broader role in maintaining organismal health than it had been suspected.
Denise P. Muñoz, Steven M. Yannone, Anneleen Daemen, Yu Sun, Funda Vakar‐Lopez, Misako Kawahara, Adam Freund, Françis Rodier, Jennifer D. Wu, Pierre-Yves Desprez, David H Raulet, Peter S. Nelson, Laura van ‘t Veer, Judith Campisi, Jean-Philippe Coppé
Léa Montégut, Flavia Lambertucci, Lucas Moledo-Nodar, Carmen Fiuza‐Luces, Carlos Rodríguez-López, José Antonio Serra Rexach, Sylvie Lachkar, Omar Motiño, Mahmoud Abdellatif, Sylvère Durand, Fanny Aprahamian, Vincent Carbonnier, Delphine Le Corre, Sophie Mouillet‐Richard, Hui Chen, Allan Sauvat, Yanbing Dong, S N Li, Rong Yan, Federico Pietrocola, Pierre Laurent‐Puig, Carlos López-Otı́n, Isabelle Martins, Clea Bárcena, Alejandro Lucı́a, Guido Guido Kroemer
Pan Juncheng, Adrien Joseph, Antoine Lafarge, Isabelle Martins, Florine Obrist, Jonathan Pol, Ester Saavedra, Sijing Li, Allan Sauvat, Giulia Cerrato, Sarah Lévesque, Marion Leduc, Oliver Kepp, Sylvère Durand, Fanny Aprahamian, Nitharsshini Nirmalathansan, Judith Michels, Guido Guido Kroemer, Maria Castedo
Discussion(0)
No comments yet. Be the first to comment.