Faculty Opinions recommendation of A lineage of myeloid cells independent of Myb and hematopoietic stem cells.

Macrophages and dendritic cells (DCs) are key components of cellular immunity and are thought to originate and renew from hematopoietic stem cells (HSCs). However, some macrophages develop in the embryo before the appearance of definitive HSCs. We thus reinvestigated macrophage development. We found that the transcription factor Myb was required for development of HSCs and all CD11b(high) monocytes and macrophages, but was dispensable for yolk sac (YS) macrophages and for the development of YS-derived F4/80(bright) macrophages in several tissues, such as liver Kupffer cells, epidermal Langerhans cells, and microglia--cell populations that all can persist in adult mice independently of HSCs. These results define a lineage of tissue macrophages that derive from the YS and are genetically distinct from HSC progeny. PMID: 22442384 Funding information This work was supported by: Biotechnology and Biological Sciences Research Council, United Kingdom Grant ID: BB/E013872/1 Medical Research Council, United Kingdom Grant ID: G1002033 Medical Research Council, United Kingdom Grant ID: G0501838 Wellcome Trust, United Kingdom Grant ID: WT081880AIA Medical Research Council, United Kingdom Grant ID: G0900867 Medical Research Council, United Kingdom Grant ID: MC_UU_12009/5 Biotechnology and Biological Sciences Research Council, United Kingdom Grant ID: BB/E013872 European Research Council, International Grant ID: 261299 Medical Research Council, United Kingdom Grant ID: G0801073 More Less keyboard_arrow_down