F<sub>4</sub> ‐ Isoprostanes as Specific Marker of Docosahexaenoic Acid Peroxidation in Alzheimer's Disease — Jaffar Nourooz‐Zadeh (1999) | RDL Network
F<sub>4</sub> ‐ Isoprostanes as Specific Marker of Docosahexaenoic Acid Peroxidation in Alzheimer's Disease
Journal of Neurochemistry 72(2): 734-740
Article 1999 English
Authors
JN
Jaffar Nourooz‐Zadeh
EL
Edwin H. C. Liu
BY
B. Yhlen
Abstract
1 min read
: F 2 ‐isoprostanes are prostaglandin‐like compounds derived from free radical‐catalysed peroxidation of arachidonic acid. Peroxidation of eicosapentaenoic acid produces F 3 ‐isoprostanes, whereas peroxidation of docosahexaenoic acid would give F 4 ‐isoprostanes. This study demonstrates the presence of esterified F 4 ‐isoprostanes in human brain and shows that levels are elevated in certain brain cortex regions in Alzheimer's disease. Our data with Alzheimer's disease suggest that analysis of F 4 ‐isoprostanes will provide new opportunities to study lipid peroxidation in the neurodegenerative diseases.
Timothy G. England, Emily R. Beatty, Almas Rehman, Jaffar Nourooz‐Zadeh, Paulo Pereira, JAMES O'REILLY, Helen Wiseman, Catherine Geissler, Barry Halliwell
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