Expression of HIV‐1 integrase in CEM cells inhibits HIV‐1 replication

Johan van Griensven; Xiaojing Zhan; Bénédicte Van Maele; Wim Pluymers; Martine Michiels; De Clercq Erik; Peter Cherepanov; Zeger Debyser

doi:10.1002/jgm.520

Abstract

1 min read

Expression of IN in CEM cells inhibits HIV-1 replication by a cumulative inhibitory effect on integration and particle production, in accord with the known pleiotropic interactions of IN. The inhibition of HIV-1 replication in CEM cells expressing the N-terminal domain of IN may lead to a novel approach for the gene therapy of AIDS.

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