Exposure to PFOA and PFOS and fetal growth: a critical merging of toxicological and epidemiological data

Eva Negri; Francesca Metruccio; Valentina Guercio; Luca Tosti; Emilio Benfenati; Rossella Bonzi; Carlo La Vecchia; Angelo Moretto

doi:10.1080/10408444.2016.1271972

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Exposure to PFOA and PFOS and fetal growth: a critical merging of toxicological and epidemiological data

Article 2017 en

Abstract

1 min read

Epidemiological and toxicological evidence suggests that PFOA and PFOS elicit a decrease in BrthW both in humans and rodents. However, the effective animal extrapolated serum concentrations are 10<sup>2</sup>-10<sup>3</sup> times higher than those in humans. Thus, there is no quantitative toxicological evidence to support the epidemiological association, thus reducing the biological plausibility of a causal relationship.

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