Exercise capacity in heart failure: a systematic review and meta-analysis of HFrEF and HFpEF disparities in VO2peak and 6-minute walking distance

HFpEF patients demonstrated superior VO_2peak, CO, and SV compared to HFrEF patients, while the observed 6MWD advantage in HFrEF was likely influenced by comorbidities. Our findings emphasize the importance of tailoring rehabilitation strategies to HF phenotype-specific physiological profiles, particularly focusing on improving VO_2peak and cardiac efficiency in HFpEF.