Exaptation of Inactivated Host Enzymes for Structural Roles in Orthopoxviruses and Novel Folds of Virus Proteins Revealed by Protein Structure Modeling

Pascal Mutz; Wolfgang Resch; Guilhem Faure; Tatiana G. Senkevich; Eugene V Koonin; Bernard Moss

doi:10.1128/mbio.00408-23

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Exaptation of Inactivated Host Enzymes for Structural Roles in Orthopoxviruses and Novel Folds of Virus Proteins Revealed by Protein Structure Modeling

Article 2023 en

Abstract

1 min read

Protein structures are more strongly conserved in evolution than are amino acid sequences. Comparative structural analysis is particularly important for inferring the origins of viral proteins that typically evolve at high rates.

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