Evidence of Subtle Gray-Matter Pathologic Changes in Healthy Elderly Individuals With Nonspecific White-Matter Hyperintensities

Domenico Maria Mezzapesa; Maria A. Rocca; Elisabetta Pagani; Gıancarlo Comı; Massimo Filippi

doi:10.1001/archneur.60.8.1109

Abstract

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This study shows that brain abnormalities in otherwise normal elderly subjects with nonspecific white-matter hyperintensities extend beyond the macroscopic white-matter lesions visualized on conventional magnetic resonance images.

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