Thyroid hormones regulate the activity of some key enzymes in lipoprotein transport. In the present study, lipid profile of patients with sub clinical hypothyroidism and overt hypothyroidism who presented at G.B.Pant Hospital, New Delhi, India was reviewed for a period of one year. Serum TSH, T4 and T3 were assayed using ELISA based kits. The concentration of serum total cholesterol, HDL- cholesterol and triglycerides were measured on Auto analyzer by standard methods. Data collected was subjected to standard statistical analysis. The patients of hypothyroidism had significantly higher levels of serum cholesterol as compared to the euthyroid controls (p < 0.05). The HDL levels were comparatively lower in the hypothyroid patients. It can be concluded that hypothyroidism is associated with dyslipidemia i.e. increased Total cholesterol and LDL- cholesterol levels and decreased HDL-cholesterol levels. Lipid disorders are probably responsible for the development of atherosclerosis in hypothyroid patients in Indian population.
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