In this issue, Deblois and colleagues show how taxane-resistant triple-negative breast cancer cells evade viral mimicry response as a result of metabolic alteration, DNA hypomethylation, and relocation of histone H3K27 trimethylation (H3K27me3). This adaptation confers a therapeutic vulnerability to the inhibition of the H3K27me3 methyltransferase EZH2 in resistant cells, leading to tumor growth inhibition by viral mimicry reactivation.See related article by Deblois et al., p. 1312.
Μαρία Γκοτζαμανίδου, Masood A. Shammas, Jun Qi, Mehmet Samur, Teru Hideshima, Meletios A Dimopoulos, Kenneth C. Anderson, James E. Bradner, Nikhil C. Munshi
Jesús Espada, Esteban Ballestar, Mario F. Fraga, Ana Villar‐Garea, Ángeles Juarranz, Juan C. Stockert, Keith D. Robertson, François Fuks, Manel Esteller
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