entation of haptoglobin production in HepSB cell Sine by a mclear factor NF-II.6

The nuclear factor N&IL6 had been suggested to be responsible for the IL-6-mediated induction of several acute-phase proteins. To obtain evidence for the involvement of NF-IL6 in the induction of acute-phase proteins, we introduced the NF-IL6 gene and its truncated mutant (delNFIL6) gene into a hepatoma cell line Hep3B. Then, we examined the effect of the overproduced NF-IL6 and delNFIL6 on the expression of haptoglobin, fibrinogen and albumin. As a result. basal production as well as induction OF haptoglobin by IL-6 were augmented by the expression of NF-IL6, whereas delNFI1~6 blocked the production of haptoglobin, fibrinogen and albumin.