Enhanced Phosphorylation of Bax and Its Translocation into Mitochondria in the Brains of Individuals Affiliated with Alzheimer’s Disease

Lauren E. Henderson; Mohamed A. Abdelmegeed; Seong Ho Yoo; Sue Goo Rhee; Xiaochun Zhu; M. A. Smith; R.Q. Nguyen; George Perry; B.J. Song

doi:10.2174/1874205x01711010048

Abstract

1 min read

The amount of phospho-p38 kinase is increased in AD brains and the activated p38 kinase appears to phosphorylate Thr residue(s) of Bax, which leads to its mitochondrial translocation, contributing to apoptosis and ultimately, neurodegeneration.

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