Engineering diaminotriazole ligands into ATP-mimetics for selective targeting of the Janus kinase 2 (JAK2) pseudokinase domain (JH2)

Maria-Elena Liosi; Stefan Krimmer; Ana S. Newton; Thomas L. Dawson; David A. Puleo; Kara J. Cutrona; Yoshihisa Suzuki; Sean Henry; Joseph Schlessinger; William L. Jorgensen

doi:10.1021/scimeetings.1c00737

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Engineering diaminotriazole ligands into ATP-mimetics for selective targeting of the Janus kinase 2 (JAK2) pseudokinase domain (JH2)

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Related publications

Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core

Covalent Modification of the JH2 Domain of Janus Kinase 2

Indoloxytriazines as binding molecules for the JAK2 JH2 pseudokinase domain and its V617F variant

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Conversion of a False Virtual Screen Hit into Selective JAK2 JH2 Domain Binders Using Convergent Design Strategies