Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease

Sabrina Büttner; Lukas Habernig; Filomena Broeskamp; Doris Ruli; F.‐Nora Vögtle; Manolis Vlachos; Francesca Macchi; Victoria Küttner; Didac Carmona‐Gutiérrez; Tobias Eisenberg; Julia Ring; Maria Markaki; Aslı Aras Taşkin; Stefan Benke; Christoph Ruckenstuhl; Ralf J. Braun; Chris Van den Haute; Tine Bammens; Anke Van der Perren; Kai‐Uwe Fröhlich; Joris Winderickx; Guido Guido Kroemer; Veerle Baekelandt; Nektarios Tavernarakis; Gábor G. Kovács; Jörn Dengjel; Chris Meisinger; Stephan J. Sigrist; Frank Madeo

doi:10.1038/emboj.2013.228

Related publications

Article2006

α‐Synuclein facilitates the toxicity of oxidized catechol metabolites: Implications for selective neurodegeneration in Parkinson's disease

Takafumi Hasegawa, Michiko Matsuzaki‐Kobayashi, Atsushi Takeda, Naoto Sugeno, Akio Kikuchi, Katsutoshi Furukawa, George Perry, Mark A. Smith, Yasuto Itoyama

Article2008

Leucine-Rich Repeat Kinase 2 Colocalizes with α-Synuclein in Parkinson’s Disease, but Not Tau-Containing Deposits in Tauopathies

George Perry, Xiongwei Zhu, Asim K. Babar, Sandra L. Siedlak, Qiwei Yang, Genta Ito, Takeshi Iwatsubo, Mark A. Smith, Shu G. Chen

Article2012

The Ca2+/Mn2+ ion-pump PMR1 links elevation of cytosolic Ca2+ levels to α-synuclein toxicity in Parkinson’s disease models

Sabrina Büttner, Liesbeth Faes, Wieland Reichelt, Filomena Broeskamp, Lukas Habernig, Stefan Benke, Nikos Kourtis, Doris Ruli, Didac Carmona‐Gutiérrez, Tobias Eisenberg, Petra D’hooge, Ruben Ghillebert, Vanessa Franssens, Alexandra Harger, Thomas R. Pieber, Paul Freudenberger, Guido Guido Kroemer, Stephan J. Sigrist, Joris Winderickx, Geert Callewaert, Nektarios Tavernarakis, Frank Madeo

Article2007

Depletion of Endonuclease G Selectively Kills Polyploid Cells

Sabrina Büttner, Didac Carmona‐Gutiérrez, Ilio Vitale, Maria Castedo, Doris Ruli, Tobias Eisenberg, Guido Guido Kroemer, Frank Madeo

Article2024

Alpha-synuclein-induced stress sensitivity renders the Parkinson’s disease brain susceptible to neurodegeneration

Modestos Nakos Bimpos, Katerina Karali, Christine Antoniou, Dionysios Palermos, Maria Fouka, Anastasios Delis, Iason Tzieras, George Chrousos, Yassemi Koutmani, Leonidas Stefanis, Alexia Polissidis