Elastin biology and tissue engineering with adult cells
Article 2013 en
Authors
CS
Cassandra B. Saitow
SW
Steven G. Wise
AW
Anthony S. Weiss
Abstract
1 min read
The inability of adult cells to produce well-organized, robust elastic fibers has long been a barrier to the successful engineering of certain tissues. In this review, we focus primarily on elastin with respect to tissue-engineered vascular substitutes. To understand elastin regulation during normal development, we describe the role of various elastic fiber accessory proteins. Biochemical pathways regulating expression of the elastin gene are addressed, with particular focus on tissue-engineering research using adult-derived cells.
Gregory H. Altman, Helen H. Lu, Rebecca L. Horan, Tara Calabro, Daniel F. Ryder, David Kaplan, Peter R. H. Stark, Iván Martín, John C. Richmond, Gordana Vunjak‐Novakovic
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