eIF2α phosphorylation: A hallmark of immunogenic cell death

Immunogenic cell death (ICD) induced by anticancer chemotherapeutics is usually preceded by premortem stress affecting the endoplasmic reticulum (ER). This ER stress does not reflect a canonical unfolded protein response (UPR) but rather manifests solely at the level of the phosphorylation of eIF2α. eIF2α phosphorylation is hence a quintessential hallmark of ICD that can be detected by immunohistochemistry in tumor samples.

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Publication Info

DOI: 10.1080/2162402x.2018.1431089
Year: 2018
Published: —
Language: en

Article Details

Volume: 7
Issue: 6
Link Of The Paper: https://doi.org/10.1080/2162402x.2018.1431089

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Created:June 19, 2026

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