Efficient Amination of Heteroaryl and Aryl Halides Using [(CyPF-<i>t-</i>Bu)PdCl₂]

[(CyPF-t-Bu)PdCl2] has been found to be a highly efficient, air- and moisture-resistant catalyst for the aminative coupling of heteroaryl chlorides, bromides and iodides to a variety of primary amines. The required catalyst loading is extremely low, most reactions give a high yield of product with 0.001-0.05 mol% of catalyst. A wide range of functional groups is tolerated in this amination reaction.