Efficacy of Chemotherapy in <i>BRCA1/2</i> Mutation Carrier Ovarian Cancer in the Setting of PARP Inhibitor Resistance: A Multi-Institutional Study — Joo Ern Ang (2013) | RDL Network
Efficacy of Chemotherapy in <i>BRCA1/2</i> Mutation Carrier Ovarian Cancer in the Setting of PARP Inhibitor Resistance: A Multi-Institutional Study
Article 2013 en
Authors
JA
Joo Ern Ang
CG
Charlie Gourley
CP
C. Bethan Powell
Abstract
1 min read
Preclinical data suggest that exposure to PARP inhibitors (PARPi) may compromise benefit to subsequent chemotherapy, particularly platinum-based regimens, in patients with BRCA1/2 mutation carrier ovarian cancer (PBMCOC), possibly through the acquisition of secondary BRCA1/2 mutations. The efficacy of chemotherapy in the PARPi-resistant setting was therefore investigated.
Joo Ern Ang, Charlie Gourley, C. Bethan Powell, Hilda High, Ronnie Shapira-Frommer, Vincent Castonguay, Jacques De Grève, Tina Atkinson, Timothy A. Yap, Shahneen Sandhu, Susana Banerjee, Lee-may Chen, Michael Friedlander, Bella Kaufman, Amit M. Oza, Ursula A. Matulonis, Louise J. Barber, Iwanka Kozarewa, Kerry Fenwick, Ioannis Assiotis, James R. Campbell, Lina Chen, Johann S. de Bono, Martin Gore, Christopher J. Lord, Alan Ashworth, Stan B. Kaye
Joo Ern Ang, Charlie Gourley, C. Bethan Powell, Hilda High, Ronnie Shapira-Frommer, Vincent Castonguay, Jacques De Grève, Tina Atkinson, Timothy A. Yap, Shahneen Sandhu, Susana Banerjee, Lee-may Chen, Michael Friedlander, Bella Kaufman, Amit M. Oza, Ursula A. Matulonis, Louise J. Barber, Iwanka Kozarewa, Kerry Fenwick, Ioannis Assiotis, James R. Campbell,
Olga Kondrashova, Monique Topp, Ksenija Nesic, Elizabeth Lieschke, Gwo‐Yaw Ho, Maria I. Harrell, Giada V. Zapparoli, Alison Hadley, Robert Holian, Emma Boehm, Valerie Heong, Elaine Sanij, Richard B. Pearson, John J. Krais, Neil Johnson, Orla McNally, Sumitra Ananda, Kathryn Alsop, Karla J. Hutt, Scott H. Kaufmann, Kevin Lin, Thomas C. Harding, Nadia Traficante, Georgia Chenevix‐Trench,
Joo Ern Ang, Charlie Gourley, C. Bethan Powell, Hilda High, Ronnie Shapira-Frommer, Vincent Castonguay, Jacques De Grève, Tina Atkinson, Timothy A. Yap, Shahneen Sandhu, Susana Banerjee, Lee-may Chen, Michael Friedlander, Bella Kaufman, Amit M. Oza, Ursula A. Matulonis, Louise J. Barber, Iwanka Kozarewa, Kerry Fenwick, Ioannis Assiotis, James R. Campbell, ,
Joo Ern Ang, Charlie Gourley, C. Bethan Powell, Hilda High, Ronnie Shapira-Frommer, Vincent Castonguay, Jacques De Grève, Tina Atkinson, Timothy A. Yap, Shahneen Sandhu, Susana Banerjee, Lee-may Chen, Michael Friedlander, Bella Kaufman, Amit M. Oza, Ursula A. Matulonis, Louise J. Barber, Iwanka Kozarewa, Kerry Fenwick, Ioannis Assiotis, James R. Campbell, ,
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