Effects of topical and subconjunctival cidofovir (HPMPC) in an animal model

Alay Banker; G Bergeron-Lynn; Kelly Keefe; De Clercq Erik; İbrahim Taşkintuna; William R. Freeman

doi:10.1080/02713689808951228

Abstract

1 min read

The IOP-decreasing effect of cidofovir occurs at doses below those causing intraocular inflammation and is likely due to an effect on the anterior segment. The anterior segment effects of cidofovir in guinea pigs were similar to those in humans. Thus, the guinea pig appears to be a good animal model for studying the effects of cidofovir on the anterior segment structures.

Discussion(0)

No comments yet. Be the first to comment.

Related publications

Article1998

Effects of topical and subconjunctival cidofovir (HPMPC) in an animalmodel

Alay Banker, G Bergeron-Lynn, Kelly Keefe, De Clercq Erik, İbrahim Taşkintuna, William R. Freeman

Article1992

Bronchial Hyperreactivity after Inhalation of Trimellitic Anhydride Dust in Guinea Pigs after Intradermal Sensitization to the Free Hapten

James Hayes, Rob Daniel, R D Tee, Peter J Barnes, Anthony J. Taylor, Kian Fan Chung

Article1983

Effect of a specific iron chelating agent on animal models of inflammation.

D R Blake, N. D. Hall, P A Bacon, Paul Dieppe, Barry Halliwell, John M.C. Gutteridge

Annals of the Rheumatic Diseases

Article1998

Influence of intravitreal injections of HPMPC and related nucleoside analogues on intraocular pressure in guinea pig eyes.

Alay Banker, De Clercq Erik, İbrahim Taşkintuna, Kelly Keefe, G Bergeron-Lynn, William R. Freeman

Article2003

Inhibition of guinea‐pig and human sensory nerve activity and the cough reflex in guinea‐pigs by cannabinoid (CB<sub>2</sub>) receptor activation

Hema J Patel, Mark A. Birrell, Natascia Crispino, David J Hele, Priya Venkatesan, Peter J Barnes, Magdi H. Yacoub, Maria G. Belvisi