The present study was conducted to know the effects of nanosilver (AgNPs) administration at NOAEL dose on biochemical parameters in Wistar rats for a period of 90 days. Thirty-five, 6-weeks-old, Wistar rats of both the sexes were divided randomly in two groups. Group 1 was kept as control and comprising of 20 rats. Group II was comprising of 15 rats and were orally administered silver nanoparticle mixed in distilled water orally at NOAEL dose rate of 30 mg/kg body weight/day from 0 day of experiment till 90th days post treatment (DPT). Blood was collected from 5 rats from each group at 0 (only from group I), 30th, 60th and 90th DPT and serum was used for biochemical studies. In group I rats, there was no significant change in any biochemical parameter at any DPT. Group II rats revealed significance increase in value was observed in ALT, AST, and cholesterol at 30th, 60th and 90th DPT as compared to group I rats. While total serum protein, serum albumin, serum gamma globulin and serum globulin levels were significantly decreased at 90th DPT in treated group as compared to control group. Serum glucose levels were also decreased at 30th, 60th and 90th DPT in treated group as compared to control. There was no significance difference in the serum calcium and serum phosphorus level in group I & II rats at any time interval. It can be concluded from the present studies that nanosilver exerted adverse effects on biochemical parameters of Wistar rats at NOAEL dose for a period of 90 days.
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