Effects of Early Life Oral Arsenic Exposure on Intestinal Tract Development and Lipid Homeostasis in Neonatal Mice: Implications for NAFLD Development

Junlai Liu; Christopher Benner; Michael Karin; Philip L.S.M. Gordts; Robert H. Tukey; Shujuan Chen; Xiaojing Yang; André Alberto Weber; Elvira Mennillo; Patrick Secrest; Max W. Chang; Samantha Wong; Sabrina Le

doi:10.1289/ehp12381

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Effects of Early Life Oral Arsenic Exposure on Intestinal Tract Development and Lipid Homeostasis in Neonatal Mice: Implications for NAFLD Development

Article 2023 en

Abstract

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Exposure to iAs in neonatal mice resulted in excessive accumulation of fat in enterocytes, disrupting lipid homeostasis in the serum and liver, revealing the importance of the gut-liver axis and endoplasmic reticulum stress in mediating iAs-induced NAFLD at an early age. https://doi.org/10.1289/EHP12381.

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Effects of Early Life Oral Arsenic Exposure on Intestinal Tract Development and Lipid Homeostasis in Neonatal Mice: Implications for NAFLD Development

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