Objective:To investigate effect of enalapril on protooncogene expression in model of chronic volume overload.Method: The rats of aorta-cava shunt were divided into treated group and non-treated group. Expression of protooncogene N-ras in left ventricle was measured by Northern blot. Result: In this model, N-ras mRNA was increased at 4 hours after operation, to the top level at 10 days after operation. The level of N-ras mRNA in treatment group was decreased at 4 hours after operation, almost disappear at 3 days after operation. Conclusion: The expression of protooncogene N-ras could be inhibited by Enalapril.
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