Effect of different antihypertensive programs on blood pressure and left ventricular hypertrophy in elderly patients with hypertension

Objective To discuss the effect of different antihypertensive programs on blood pressure and left ven-tricular hypertrophy of elderly patients with hypertension, and to provide a guidance for clinical practice. Methods A total of 162 patients with hypertension in Department of Internal Medicine in our hospital were selected from December 2012 to December 2014, and randomly divided into the observation group and the control group according to random number table, with 81 patients in each group. The observation group was treated by amlodipine combined with hydrochlorothi-azide, and the control group was treated with amlodipine combined with irbesartan, for a treatment course of two mouths. The blood pressure, left ventricular mass index (LVMI), after treatment were compared between the two groups. Results Among the 162 patients, eight patients were lost to follow-up. After treatment, the systolic blood pres-sure of patients in observation group and the control group was (123 ± 6) mmHg, (129 ± 8) mmHg, respectively, which were significantly decreased compared with those before treatment [(157 ± 12) mmHg, (156 ± 9) mmHg], and the value was significantly lower in observation group than control group (P<0.05). After treatment, the degree of LVMI were sig-nificantly reduced compared with before treatment, and the LVMI in observation group was significantly lower than that in the control group [(124±18) g/m2 vs (132±16) g/m2, P<0.05]. Conclusion Amlodipine combined with irbesartan and amlodipine combined with hydrochlorothiazide can both reduce blood pressure and LVMI of patients. However, the treat-ment effect of amlodipine combined with hydrochlorothiazide is more significant, which is worthy of clinical populariza-tion and application.