Dynamic gray matter volume changes in pediatric multiple sclerosis

Ermelinda De Meo; Alessandro Meani; Lucia Moiola; Angelo Ghezzi; Pierangelo Veggiotti; Massimo Filippi; Maria A. Rocca

doi:10.1212/wnl.0000000000007267

Abstract

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Impaired GM maturation occurs in pediatric patients with MS, which is only partially driven by WM inflammation, suggesting that early neurodegenerative phenomena contribute to disability. High IQ, a measure of reserve, may offer protection by promoting remodeling of GM pruning in this young age.

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