Disruption of Structural Connectivity along the Dorsal and Ventral Language Pathways in Patients with Nonfluent and Semantic Variant Primary Progressive Aphasia (P06.070)

OBJECTIVE: We wished to determine the patterns of white matter (WM) microstructural damage along individual dorsal and ventral language WM pathways and corpus callosum in patients with nonfluent (NFV) and semantic (SV) variants of primary progressive aphasia (PPA). To this end, we combined the unique ability of probabilistic diffusion tensor (DT) tractography to reconstruct WM structural connections with that of Tract-Based Spatial Statistics to perform a voxel-wise analysis in order to capture the subset of voxels specifically abnormal in individual WM tracts of NFV and SV patients.