Disease Severity and Effective Parasite Multiplication Rate in Falciparum Malaria
Open Forum Infectious Diseases 4(4)
Article 2017 English
Authors
HK
Hugh Kingston
AG
Aniruddha Ghose
KP
Katherine Plewes
Abstract
1 min read
Patients presenting with severe falciparum malaria in a Bangladeshi tertiary hospital had higher total parasite burden, estimated by parasitemia and plasma PfHRP2, than uncomplicated malaria patients despite shorter fever duration. This suggests that higher parasite multiplication rates (PMR) contribute to causing the higher biomass found in severe disease. Compared with patients without a history of previous malaria, patients with previous malaria carried a lower parasite biomass with similar fever duration at presentation, suggesting that host immunity reduces the PMR.
Mallika Imwong, Charles J. Woodrow, Ilse C. E. Hendriksen, Jacobien Veenemans, Hans Verhoef, Maryam Faiz, Sanjib Mohanty, Saroj K. Mishra, George Mtove, Samwel Gesase, Amir Seni, Kajal Chhaganlal, Nicholas P. J. Day, Arjen M. Dondorp, Sir Nicholas White
Arjen M. Dondorp, Varunee Desakorn, Wirichada Pongtavornpinyo, Duangjai Sahassananda, Kamolrat Silamut, Kesinee Chotivanich, Paul N. Newton, Punnee Pitisuttithum, Anthony M. Smithyman, Sir Nicholas White, Nicholas Day
Haruhiko Ishioka, Aniruddha Ghose, Prakaykaew Charunwatthana, Richard J. Maude, Katherine Plewes, Hugh W. F. Kingston, Benjamas Intharabut, Charlie Woodrow, Kesinee Chotivanich, Abdullah Abu Sayeed, Mahtab Uddin Hasan, Nicholas Day, Abul Faiz, Sir Nicholas White, Amir Hossain, Arjen M. Dondorp
Discussion(0)
No comments yet. Be the first to comment.