Discovery of uracil-bearing DAPYs derivatives as novel HIV-1 NNRTIs via crystallographic overlay-based molecular hybridization

Heng Zhang; Ye Tian; Dongwei Kang; Zhipeng Huo; Zhongxia Zhou; Huiqing Liu; De Clercq Erik; Christophe Pannecouque; Peng Zhan; Xinyong Liu

doi:10.1016/j.ejmech.2017.02.047

Related publications

Article2014

Discovery of 2-pyridone derivatives as potent HIV-1 NNRTIs using molecular hybridization based on crystallographic overlays

Wen‐Ming Chen, Peng Zhan, Diwakar Rai, De Clercq Erik, Christophe Pannecouque, Jan Balzarini, Zhongxia Zhou, Huiqing Liu, Xinyong Liu

Article2022

Disubstituted pyrimidine-5-carboxamide derivatives as novel HIV-1 NNRTIs: Crystallographic overlay-based molecular design, synthesis, and biological evaluation

Da Feng, Hao Lin, Liyang Jiang, Jiaojiao Dai, Xiaoying Zhang, Zhongxia Zhou, Yanying Sun, Zhao Wang, De Clercq Erik, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu

Article2017

Discovery of novel DAPY-IAS hybrid derivatives as potential HIV-1 inhibitors using molecular hybridization based on crystallographic overlays

Boshi Huang, Xueshun Wang, Xinhao Liu, Zihui Chen, Wanzhuo Li, Songkai Sun, Huiqing Liu, Dirk Daelemans, De Clercq Erik, Christophe Pannecouque, Peng Zhan, Xinyong Liu

Article2016

Arylazolyl(azinyl)thioacetanilides. Part 20: Discovery of novel purinylthioacetanilides derivatives as potent HIV-1 NNRTIs via a structure-based bioisosterism approach

Xueyi Lu, Xiao Li, Jiapei Yang, Boshi Huang, Dongwei Kang, Fabao Zhao, Zhongxia Zhou, De Clercq Erik, Dirk Daelemans, Christophe Pannecouque, Peng Zhan, Xinyong Liu

Article2019

Discovery of novel indolylarylsulfones as potent HIV-1 NNRTIs via structure-guided scaffold morphing

Tong Zhao, Qing Meng, Dongwei Kang, Jianbo Ji, De Clercq Erik, Christophe Pannecouque, Xinyong Liu, Peng Zhan