Difluorinated carbaacyclonucleosides: Synthesis and evaluation of antiviral activity

Maureen Lewis; De Clercq Erik

doi:10.3184/030823401103170061

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Difluorinated carbaacyclonucleosides: Synthesis and evaluation of antiviral activity

Article 2001 en

Abstract

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The synthesis of 4-benzoyloxy-5,5-difluoropentan-1-ol from ethyl difluoroacetate is described; its condensation with pyrimidine bases gave carbaacyclonucleosides. which were evaluated, and found inactive, in a large variety of antiviral assays.

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