Differential Proteomics of Cardiovascular Risk and Coronary Artery Disease in Humans

Ele Ferrannini; Maria Laura Manca; Giulia Ferrannini; Felicita Andreotti; Daniele Andreini; Roberto Latini; Marco Magnoni; Stephen A. Williams; Attilio Maseri; Aldo Maggioni

doi:10.3389/fcvm.2021.790289

Abstract

1 min read

In a CCTA-based cohort, four proteins, involved in opposing vascular processes (healing vs. adverse remodeling), are specifically associated with low CAD burden in high CV-risk individuals (high MYO and C-C-22) and high CAD burden in low-risk subjects (high PS-3 and PAF-AH), in interaction with BMI, smoking, diabetes, HDL-cholesterol, and HbA<sub>1c</sub>. These findings could contribute to a deeper understanding of the atherosclerotic process beyond traditional risk profile assessment and potentially constitute new treatment targets.

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