Differential Effects of NOD2 Variants on Crohn's Disease Risk and Phenotype in Diverse Populations: A Metaanalysis

Michael Economou; Thomas A Trikalinos; Konstantinos T. Loizou; Epameinondas V. Tsianos; John P A Ioannidis

doi:10.1111/j.1572-0241.2004.40304.x

Abstract

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SNP8, SNP12, and SNP13 have differential effects on CD risk, with SNP13 having the strongest genetic effect. These NOD2 variants are also significant risk factors for CD phenotype, in particular ileal location.

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