Differential Effects of Immunosuppressive Drugs on Chemokine Receptor CCR7 in Human Monocyte-Derived Dendritic Cells: Selective Upregulation by Rapamycin

Valeria Sordi; Giuseppe Bianchi; Chiara Buracchi; Alessia Mercalli; Federica Marchesi; Giovanna D’Amico; Cui-Hong Yang; Walter Luini; Annunciata Vecchi; Alberto Mantovani; Paola Allavena; Lorenzo Piemonti

doi:10.1097/01.tp.0000235433.03554.4f

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Alberto Mantovani

Differential Effects of Immunosuppressive Drugs on Chemokine Receptor CCR7 in Human Monocyte-Derived Dendritic Cells: Selective Upregulation by Rapamycin

Article 2006 en

Authors

VS
Valeria Sordi
GB
Giuseppe Bianchi
CB
Chiara Buracchi

Abstract

1 min read

These findings demonstrate that immunosuppressive agents differently modulate the CKR switch associated with maturing DC; in particular, RAPA selectively up-regulates CCR7 and enhances the migration of differentiated DC to regional LN. This study contributes to a better understanding of the role of immunosuppressive therapy on DC migration, a potentially relevant check point of immunosuppressive treatment.

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Differential Effects of Immunosuppressive Drugs on Chemokine Receptor CCR7 in Human Monocyte-Derived Dendritic Cells: Selective Upregulation by Rapamycin

Abstract

Discussion(0)

Related publications

Differential signalling of the chemokine receptor CXCR4 by stromal cell‐derived factor 1 and the HIV glycoprotein in rat neurons and astrocytes

Selective contribution of IFN-α/β signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection

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Human monocyte‐derived and CD34<sup>+</sup> cell‐derived dendritic cells express functional receptors for platelet activating factor