Differential Effects of HDAC6 Inhibition Versus Knockout During Hepatic Ischemia–reperfusion Injury Highlight Importance of HDAC6 C-terminal Zinc-finger Ubiquitin-binding Domain
Article 2024 en
Authors
SC
Seth J. Concors
PH
Paul T. Hernandez
CO
Ciaran O’Brien
Abstract
1 min read
Ischemia-reperfusion injury (IRI) causes significant morbidity in liver transplantation among other medical conditions. IRI following liver transplantation contributes to poor outcomes and early graft loss. Histone/protein deacetylases (HDACs) regulate diverse cellular processes, play a role in mediating tissue responses to IRI, and may represent a novel therapeutic target in preventing IRI in liver transplantation.
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