Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling

Nynke M. S. van den Akker; Vincenza Caolo; Lambertus J. Wisse; Patricia P.W.M. Peters; Robert E. Poelmann; Peter Carmeliet; Daniël G. M. Molin; Adriana C. Gittenberger–de Groot

doi:10.1093/cvr/cvm108

Abstract

1 min read

We demonstrate that VEGF isoform-related spatiotemporal cardiac alterations in the VEGF/Notch/ephrinB2 cascade lead to disturbed coronary development. This knowledge can contribute to optimizing therapies targeting VEGF signalling by enabling balancing between angiogenesis and vascular maturation.

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