Detection of oligomers and fibrils of α-synuclein by AIEgen with strong fluorescence
Article 2014 en
Authors
CL
Chris Wai Tung Leung
FG
Feng Guo
YH
Yuning Hong
Abstract
1 min read
We report a fluorophore, TPE-TPP, with AIE characteristics which is utilized as a fluorescence probe to monitor the α-synuclein (α-Syn) fibrillation process. Compared with ThT, TPE-TPP shows a higher sensitivity in the detection of α-Syn oligomers as well as fibrils with a stronger fluorescence. The performance of TPE-TPP was evaluated using fluorescence, AFM, dot blot, and SEC.
Ahmed A. Elbatrawy, Taiwo A. Ademoye, Heba Alnakhala, Arati Tripathi, Germán Plascencia‐Villa, Xiongwei Zhu, George Perry, Ulf Dettmer, Jessica S. Fortin
Ahmed A. Elbatrawy, Taiwo A. Ademoye, Heba Alnakhala, Arati Tripathi, Xiongwei Zhu, Germán Plascencia‐Villa, George Perry, Ulf Dettmer, Jessica S. Fortin
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